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(Z) -4EGI-1

Product Specifications

CAS Number

901787-88-0

Target

Others|||PERK

Related Pathways

Apoptosis|||Others

Bioactivity

(Z) -4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 ?M and a Kd value of 8.74 ?M. Notably, (Z) -4EGI-1 possesses anticancer activity[1][2].

Smiles

N(/N=C(/CC1=C(N(=O)=O)C=CC=C1)\C(O)=O)C2=NC(=CS2)C3=CC(Cl)=C(Cl)C=C3

Molecular Formula

C18H12Cl2N4O4S

Molecular Weight

451.28

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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