Canagliflozin (hemihydrate)
Product Specifications
UNSPSC Description
Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[1].
Target Antigen
SGLT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Canagliflozin-hemihydrate.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC1=CC=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1CC3=CC=C(C4=CC=C(F)C=C4)S3.[0.5H2O]
Molecular Weight
453.52
References & Citations
[1]Liang Y, et al. 
Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.
PLoS One. 2012;7(2):e30555.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-I0383/Canagliflozin-hemihydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-I0383/Canagliflozin-hemihydrate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
928672-86-0
Available Sizes
Curated Selection
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