TL13-22
Product Specifications
CAS Number
2229036-65-9
Target
ALK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9913
Bioactivity
TL13-22 is a potent inhibitor of Anaplastic Lymphoma Kinase (ALK) with an IC50 value of 0.54 nM and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 (induces ALK protein degradation) as a negative control.TL13-22 also induces degradation of other kinases, including Aurora A, FER, PTK2, and RPS6KA1.
Smiles
O=C1C=2C=CC=C(NCC(=O)NCCOCCOCCN3CCN(C4=CC=C(NC5=NC=C(Cl)C(=N5)NC=6C=CC=CC6S(=O)(=O)C(C)C)C(OC)=C4)CC3)C2C(=O)N1C7C(=O)NCCC7
Molecular Formula
C45H55ClN10O9S
Molecular Weight
947.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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