BP-1-102
Product Specifications
CAS Number
1334493-07-0
Target
STAT
Related Pathways
JAK/STAT signaling, Stem Cells
Purity
0.9981
Bioactivity
BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of [c-Myc, Bcl-xL, Cyclin D1, Survivin, and VEGF].
Smiles
CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Molecular Formula
C29H27F5N2O6S
Molecular Weight
626.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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