Pyridomycin
Product Specifications
CAS Number
18791-21-4
Target
Others, Antibiotic, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3- (3-pyridyl) -L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml) .
Smiles
C([C@@H]1NC(=O)[C@@H](NC(=O)C2=C(O)C=CC=N2)[C@@H](C)OC(=O)\C(=C(\CC)/C)\OC(=O)[C@H](C)[C@@H]1O)C=3C=CC=NC3
Molecular Formula
C27H32N4O8
Molecular Weight
540.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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