NR-160
Product Specifications
CAS Number
2484895-50-1
Target
Others, HDAC
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic, Others
Bioactivity
NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50= 0.03 μM) .1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 μM, respectively) . NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 μM) . It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.
Smiles
N(C(=O)C1=C(C(F)(F)F)C=CC=C1)(CC=2N(CC3=CC=CC=C3)N=NN2)CC4=CC=C(C(NO)=O)C=C4
Molecular Formula
C25H21F3N6O3
Molecular Weight
510.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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