Laulimalide
Product Specifications
CAS Number
115268-43-4
Target
Apoptosis, Microtubule Associated, Others
Related Pathways
Others, Apoptosis, Cytoskeletal Signaling
Bioactivity
Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used) . Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.
Smiles
O[C@@H]1[C@]2([C@@](O2)(C[C@@]([C@H](/C=C/[C@@H]3CC(C)=CCO3)O)(OC(=O)/C=C/C[C@]4(O[C@](C[C@@H](C)CC(=C)C1)(CC=C4)[H])[H])[H])[H])[H]
Molecular Formula
C30H42O7
Molecular Weight
514.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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