PtdIns- (3,4,5) -P3-biotin (sodium salt)

The PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns- (3,4,5) -P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns- (3,4,5) -P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol- (3,4,5) -triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.

[Na].[Na].[Na].[Na].[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]3O)OC(=O)CCCCCCC)[C@@]1([H])NC(=O)N2