PtdIns- (3,4,5) -P3 (1,2-dipalmitoyl) (sodium salt)

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns- (3,4,5) -P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns- (3,4,5) -P3-binding proteins. Protein-binding to PtdIns- (3,4,5) -P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns- (3,4,5) -P3 is resistant to cleavage by PI-specific phospholipase C (PLC) . Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates.

[Na].[Na].[Na].[Na].CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCCCCCCCCCC