Endosidin-2
Product Specifications
CAS Number
1839524-44-5
Target
Others
Related Pathways
Others
Purity
0.9829
Bioactivity
Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1) .Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.
Smiles
COC1=CC(\C=N\NC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O
Molecular Formula
C15H12FIN2O3
Molecular Weight
414.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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