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Endosidin-2

Product Specifications

CAS Number

1839524-44-5

Target

Others

Related Pathways

Others

Purity

0.9829

Bioactivity

Endosidin-2 is an exocyst inhibitor, a cell-permeable benzylidene benzoylhydrazine, that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1) .Endosidin-2 disrupts protein translocation between the endosomes and plasma membrane, thereby facilitating translocation of proteins to the vesicle for degradation. It also inhibits recirculation of endocytosed transferrin to the plasma membrane in HeLa cells and targets multiple isoforms of mammalian EXO70, leading to dysregulation of exocytosis.Endosidin2 can be used as a tool molecule to study cytosolization.

Smiles

COC1=CC(\C=N\NC(=O)C2=CC=CC(F)=C2)=CC(I)=C1O

Molecular Formula

C15H12FIN2O3

Molecular Weight

414.17

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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