Reveromycin A
Product Specifications
CAS Number
134615-37-5
Target
Others, Antifungal, Apoptosis, Antibiotic
Related Pathways
Apoptosis, Others, Microbiology/Virology
Bioactivity
Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3) . Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in osteoclasts with an IC50 value of 0.7 μM.
Smiles
CCCC[C@]1(CC[C@]2(CC[C@H](C)[C@@H](C\C=C(/C)\C=C\[C@H](O)[C@@H](C)\C=C\C(O)=O)O2)O[C@H]1\C=C\C(\C)=C\C(O)=O)OC(=O)CCC(O)=O
Molecular Formula
C36H52O11
Molecular Weight
660.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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