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MRT 67307 dihydrochloride

Product Specifications

CAS Number

1781882-89-0

Target

Autophagy, IκB/IKK, SIK

Related Pathways

NF-κB, Autophagy, PI3K/Akt/mTOR signaling

Purity

0.9975

Bioactivity

MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

Smiles

O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.Cl.Cl

Molecular Formula

C26H38Cl2N6O2

Molecular Weight

537.53

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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