MRT 67307 dihydrochloride
Product Specifications
CAS Number
1781882-89-0
Target
Autophagy, IκB/IKK, SIK
Related Pathways
NF-κB, Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9975
Bioactivity
MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.
Smiles
O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.Cl.Cl
Molecular Formula
C26H38Cl2N6O2
Molecular Weight
537.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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