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GSK 591 dihydrochloride

Product Specifications

CAS Number

2320953-89-5

Target

Others, Histone Methyltransferase

Related Pathways

Chromatin/Epigenetic, Others

Bioactivity

Potent and selective PRMT5 inhibitor (IC50 = 4 nM) . Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro. To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

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Cl.Cl.O[C@@H](CNC(=O)c1ccnc(NC2CCC2)c1)CN1CCc2ccccc2C1

Molecular Formula

C22H30Cl2N4O2

Molecular Weight

453.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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