Malformin C
Product Specifications
CAS Number
59926-78-2
Target
Others, Reactive Oxygen Species
Related Pathways
Metabolism, Immunology/Inflammation, Others, NF-κB
Bioactivity
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM) . It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM) . Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but has a low therapeutic index against cancer xenografts when tested in mice.
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[H][C@@]12CSSC[C@@]([H])(NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)C(NC1=O)C(C)C)C(=O)N2 |@@:31|
Molecular Formula
C23H39N5O5S2
Molecular Weight
529.72
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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