PKUMDL-LC-101-D04
Product Specifications
CAS Number
2143896-83-5
Target
GPX, Glutathione Peroxidase
Related Pathways
Oxidation-Reduction, Metabolism
Purity
0.9965
Bioactivity
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
Smiles
Cl.NCCNS(=O)(=O)c1ccc(NC(=S)NC2CCCC2)cc1
Molecular Formula
C14H23ClN4O2S2
Molecular Weight
378.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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