Ruboxistaurin mesylate
Product Specifications
CAS Number
192050-59-2
Target
Others, PKC
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Others
Bioactivity
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Smiles
S(C)(=O)(=O)O.O=C1C2=C(C=3C=4C(N(C3)CCO[C@H](CN(C)C)CCN5C=C2C=6C5=CC=CC6)=CC=CC4)C(=O)N1
Molecular Formula
C29H32N4O6S
Molecular Weight
564.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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