CAY10773

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 ?M, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 ?M) . CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 ?M but induces ferroptosis at concentrations greater than or equal to 6 ?M with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (?6 ?M) also induces autophagy with incubation times longer than eight hours.