Ac-FLTD-CMK
Product Specifications
CAS Number
2376255-48-8
Target
Pyroptosis, Caspase
Related Pathways
Immunology/Inflammation, Apoptosis, Proteases/Proteasome
Purity
0.9861
Bioactivity
Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 μM and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3.
Smiles
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CCl
Molecular Formula
C26H37ClN4O8
Molecular Weight
569.05
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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