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Ac-FLTD-CMK

Product Specifications

CAS Number

2376255-48-8

Target

Pyroptosis|||Caspase

Related Pathways

Immunology/Inflammation|||Apoptosis|||Proteases/Proteasome

Purity

0.9861

Bioactivity

Ac-FLTD-CMK is an inhibitor derived from abscisicin D (GSDMDD) with specific inhibitory effects on inflammatory caspases. ac-FLTD-CMK showed inhibitory effects on caspases-1, caspases-4 and caspases-11 with IC50s of 46.7 nM, 1.49 ?M and 329 nM, respectively. Ac-FLTD-CMK showed potency against caspases-1, caspases-4 and caspases-11, but not against apoptosis-associated caspase-3.

Smiles

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CCl

Molecular Formula

C26H37ClN4O8

Molecular Weight

569.05

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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