AAQ chloride

Photoswitchable Kv channel blocker (IC50 values are 2 and 64 ?M at 500 nm and 380 nm respectively) . Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-type Ca2+ channels. Stimulates action potential firing of hippocampal neurons in vitro at 500 nm and restores visual responsiveness in blind mice at 380 nm.