Binucleine 2
Product Specifications
CAS Number
220088-42-6
Target
Others|||Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint|||Others|||Chromatin/Epigenetic
Bioactivity
Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 ?M), specifically inhibiting it in a dose-dependent manner while exhibiting minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 ?M. At 40 ?M, Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells and prevents the assembly of a contractile ring during cell division in Drosophila S2 cells, but it does not affect ring ingression, indicating that Aurora B kinase activity is not required for that process.
Smiles
N(=CN(C)C)C=1N(N=CC1C#N)C2=CC(Cl)=C(F)C=C2
Molecular Formula
C13H11ClFN5
Molecular Weight
291.71
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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