Filipin II
Product Specifications
CAS Number
38620-77-8
Target
Antifungal, Others, Antibiotic
Related Pathways
Microbiology/Virology, Others
Bioactivity
Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml) . Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml) .[3]
Smiles
CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C/[C@H](O)[C@@H](C)OC1=O |c:36,t:28,30,32,34|
Molecular Formula
C35H58O10
Molecular Weight
638.839
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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