BPIQ-II (hydrochloride)
Product Specifications
CAS Number
171179-37-6
Target
Others|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Others
Bioactivity
BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM) . It is selective for EGFR over other tyrosine and serine/threonine kinases, and cellular studies show that BPIQ-II can selectively inhibit EGF-stimulated signal transmission by competitively binding at the ATP site of EGFR.
Smiles
Cl.BrC1=CC=CC(=C1)NC2=NC=NC3=CC=4N=CNC4C=C32
Molecular Formula
C15H11BrClN5
Molecular Weight
376.64
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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