Entrectinib
Product Specifications
CAS Number
1108743-60-7
Target
ROS Kinase, Autophagy, ROS, ALK, Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors, Immunology/Inflammation, Angiogenesis, Autophagy
Purity
0.9961
Bioactivity
Entrectinib (RXDX-101) is a Trk, ROS1, and ALK inhibitor that inhibits TrkA, TrkB, TrkC, ROS1, and ALK (IC50=1/3/5/12/7 nM) with oral activity and blood-brain-barrier penetration. Entrectinib exhibits both antitumor and CNS activity.
Smiles
N(C(=O)C1=C(NC2CCOCC2)C=C(C=C1)N3CCN(C)CC3)C=4C=5C(NN4)=CC=C(CC6=CC(F)=CC(F)=C6)C5
Molecular Formula
C31H34F2N6O2
Molecular Weight
560.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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