Heliquinomycin
Product Specifications
CAS Number
178182-49-5
Target
Others|||DNA/RNA Synthesis|||Antibacterial|||Topoisomerase
Related Pathways
Microbiology/Virology|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others
Bioactivity
Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis, and methicillin-sensitive or -resistantS. aureus (MICs = <0.05-0.39 ?g/ml) . Heliquinomycin inhibits the activity of DNA helicase with a Kivalue of 6.8 ?M. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 ?g/ml, respectively) .
Smiles
CO[C@@H]1C[C@H](O[C@@H]2c3c(O[C@@]22Oc4c(C[C@H]2O)cc2cc(oc(=O)c2c4O)C(=O)OC)c(O)c2C(=O)C(OC)=CC(=O)c2c3O)O[C@@H](C)[C@@H]1O|c:42|
Molecular Formula
C33H30O17
Molecular Weight
698.586
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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