Tie2 Inhibitor 7
Product Specifications
CAS Number
1020412-97-8
Target
Others, Tie-2
Related Pathways
Tyrosine Kinase/Adaptors, Others
Bioactivity
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
Smiles
C(O)(=O)C1=CC(C2=CC=C(CN(C(OC3=CC=C(C)C=C3)=O)CC(N[C@@H](C)C4CCCCC4)=O)C=C2)=CN=C1
Molecular Formula
C31H35N3O5
Molecular Weight
529.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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