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Tie2 Inhibitor 7

Product Specifications

CAS Number

1020412-97-8

Target

Others|||Tie-2

Related Pathways

Tyrosine Kinase/Adaptors|||Others

Bioactivity

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 ?M.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 ?M. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.

Smiles

C(O)(=O)C1=CC(C2=CC=C(CN(C(OC3=CC=C(C)C=C3)=O)CC(N[C@@H](C)C4CCCCC4)=O)C=C2)=CN=C1

Molecular Formula

C31H35N3O5

Molecular Weight

529.63

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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