RWJ-56110 dihydrochloride
Product Specifications
CAS Number
2387505-58-8
Target
Protease-activated Receptor, Others, Apoptosis
Related Pathways
Others, GPCR/G Protein, Apoptosis
Bioactivity
RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 μM), showing no effect on PAR-2, PAR-3, or PAR-4. It inhibits the aggregation of human platelets induced by SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), with high selectivity relative to U46619. RWJ-56110 dihydrochloride also blocks angiogenesis and the formation of new vessels in vivo, and induces cell apoptosis[1][2].
Smiles
Cl.Cl.NCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)Nc1ccc2c(CN3CCCC3)cn(Cc3c(Cl)cccc3Cl)c2c1)C(=O)NCc1ccccc1
Molecular Formula
C41H44Cl3F2N7O3
Molecular Weight
827.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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