CCT241533 dihydrochloride
Product Specifications
CAS Number
1962925-28-5
Target
Others, Chk
Related Pathways
Others, Cell Cycle/Checkpoint
Bioactivity
Potent Chk2 inhibitor (IC50 = 3 nM) . Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
Smiles
Cl.Cl.COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O
Molecular Formula
C23H29Cl2FN4O4
Molecular Weight
515.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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