FD-211

FD-211 is a ? lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 ?g/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 ?g/ml) . FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 ?g/ml for all) .