Ipivivint
Product Specifications
CAS Number
1481617-15-5
Target
Others, Wnt/beta-catenin, CDK
Related Pathways
Cell Cycle/Checkpoint, Others, Stem Cells, Cytoskeletal Signaling
Bioactivity
Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM) . Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1].
Smiles
CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1
Molecular Formula
C26H21FN8
Molecular Weight
464.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
11070100-AAT 100 Tests
MFluor™ Violet 500 Anti-human/ non-human primates/ mouse CD107a Antibody *H4A3*
Sign In for Pricing
View Details 
MBS9428117-02 5x 96 Tests
Human C-type mannose receptor 2 ELISA Kit
Sign In for Pricing
View Details