Ipivivint
Product Specifications
CAS Number
1481617-15-5
Target
Others|||Wnt/beta-catenin|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Others|||Stem Cells|||Cytoskeletal Signaling
Bioactivity
Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 ?M), CLK2 (IC50=0.002 ?M) and CLK3 (IC50=0.022 ?M) . Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1].
Smiles
CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1
Molecular Formula
C26H21FN8
Molecular Weight
464.5
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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