SM1-71
Product Specifications
CAS Number
2088179-99-9
Target
FGFR, LIM Kinase, Serine/threonin kinase, MAPK, TGF-beta/Smad, Src, S6 Kinase, AAK1
Related Pathways
Neuroscience, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Angiogenesis, MAPK, Metabolism, Stem Cells
Purity
0.96
Bioactivity
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.
Smiles
CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3NC(=O)C=C)n2)cc1
Molecular Formula
C24H26ClN7O
Molecular Weight
463.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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