CAY10561
Product Specifications
CAS Number
933786-58-4
Target
ERK, Others
Related Pathways
Others, MAPK
Bioactivity
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM) . This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM) . CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.
Smiles
C(NC(CO)C1=CC(Cl)=C(F)C=C1)(=O)C2=CC(C=3C(=CNN3)C4=CC(Cl)=CC=C4)=CN2
Molecular Formula
C22H17Cl2FN4O2
Molecular Weight
459.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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