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RAS inhibitor Abd-7

Product Specifications

CAS Number

2351843-48-4

Target

Kras, Others, Ras

Related Pathways

GPCR/G Protein, MAPK, Others

Bioactivity

RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].

Smiles

COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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