RAS inhibitor Abd-7
Product Specifications
CAS Number
2351843-48-4
Target
Kras|||Others|||Ras
Related Pathways
GPCR/G Protein|||MAPK|||Others
Bioactivity
RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
Smiles
COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12
Molecular Formula
C23H25N3O3
Molecular Weight
391.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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