Antileukinate
Product Specifications
CAS Number
138559-60-1
Target
CXCR
Related Pathways
Immunology/Inflammation|||Autophagy|||GPCR/G Protein
Bioactivity
Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 ?M), prevents neutrophil chemotaxis and ?-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.
Smiles
C([C@@H](C(N[C@@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CS)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O)C=3C=4C(NC3)=CC=CC4
Molecular Formula
C45H66N18O7S
Molecular Weight
1003.19
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/A17617AF-3BFD-4AE7-88BA-DEEE3741216D/T36623
Available Sizes
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