Quazinone
Product Specifications
CAS Number
70018-51-8
Target
Others, MAPK, PDE
Related Pathways
Others, MAPK, Metabolism
Bioactivity
Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties. It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM), increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner (10-300 μg/kg), decreases systolic and diastolic blood pressure, and inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.
Smiles
C[C@H]1N2C(NC=3C(C2)=C(Cl)C=CC3)=NC1=O
Molecular Formula
C11H10ClN3O
Molecular Weight
235.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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