IL-4-inhibitor-1
Product Specifications
CAS Number
1332184-63-0
Target
Interleukin|||IL Receptor
Related Pathways
Immunology/Inflammation
Purity
>99.99%
Bioactivity
IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 ?M and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 ?M) . It is selective for IL-4 over IL-13 (EC50= 18.2 ?M) . IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 ?M), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
Smiles
Nc1nc(cc(-c2ccc(O)c(O)c2)c1C#N)-c1ccc(F)cc1
Molecular Formula
C18H12FN3O2
Molecular Weight
321.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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