Alaproclate (hydrochloride)
Product Specifications
CAS Number
60719-83-7
Target
Others|||Serotonin Transporter|||5-HT Receptor|||iGluR
Related Pathways
Membrane transporter/Ion channel|||GPCR/G Protein|||Others|||Neuroscience
Bioactivity
Alaproclate is a selective serotonin reuptake inhibitor (SSRI) .1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-?-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively) .1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 ?M, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 ?M.2 It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4; IC50 = 2.3 ?M) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily.3 Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.4
Smiles
Cl.O=C(OC(C)(C)CC1=CC=C(Cl)C=C1)C(N)C
Molecular Formula
C13H19Cl2NO2
Molecular Weight
292.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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