Resveratrol-3-O-sulfate sodium

Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 ?M) decreases the expression of IL-1?, IL-1?, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-? and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 ?M, and induces apoptosis at concentrations of 25 and 50 ?M. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 ?M for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.