CMC2.24
Product Specifications
CAS Number
1255639-43-0
Target
Apoptosis, Ras, MMP, Others
Related Pathways
GPCR/G Protein, MAPK, Others, Proteases/Proteasome, Apoptosis
Bioactivity
CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis through the NF-κB/HIF-2α axis[1][2][3].
Smiles
Oc1ccc(\C=C\C(=O)C(C(=O)Nc2ccccc2)C(=O)\C=C\c2ccc(O)cc2)cc1
Molecular Formula
C26H21NO5
Molecular Weight
427.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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