TunR2

TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis (MIC = 0.3 ?g/ml) and increases the efficacy of the ?-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 ?g/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae (MIC = >10 ?g/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared with tunicamycin.