ARN14988
Product Specifications
CAS Number
1502027-70-4
Target
Others
Related Pathways
Others
Bioactivity
ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme) . It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively) .
Smiles
C(OCC(C)C)(=O)N1C(=O)N(C(NCCCCCC)=O)C=C(Cl)C1=O
Molecular Formula
C16H24ClN3O5
Molecular Weight
373.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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