Chlorin E6
Product Specifications
CAS Number
19660-77-6
Target
Parasite, Photosensitizer, Apoptosis, Caspase, Bcl-2 Family, PARP
Related Pathways
Microbiology/Virology, Proteases/Proteasome, Apoptosis, DNA Damage/DNA Repair, Chromatin/Epigenetic
Purity
0.9505
Bioactivity
Chlorin E6 (CE6) is a second-generation photosensitizer with antitumor activity when used in combination with irradiation. In a mouse model of implanted fibrosarcoma, Chlorin E6 (2.5-10 mg/kg, i.v., 50-200 J/cm2 irradiation) resulted in complete tumor disappearance after varying degrees of irradiation. Agents including Chlorin E6 were tested in a Phase I clinical study in patients with early superficial squamous cell carcinoma of bronchial origin with favorable results (40 mg/m2, IV, 100 J/cm2 laser irradiation) . In a Phase II clinical trial in patients with early stage lung cancer, the same mode of administration resulted in a complete response in 82.9% of patients. Chlorin E6 has been investigated as a nanotechnology drug delivery tool.
Smiles
CCc1c(C)c2cc3[nH]c(cc4nc([C@@H](CCC(O)=O)[C@@H]4C)c(CC(O)=O)c4[nH]c(cc1n2)c(C)c4C(O)=O)c(C)c3C=C
Molecular Formula
C34H36N4O6
Molecular Weight
596.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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