RSL3
Product Specifications
CAS Number
1219810-16-8
Target
Glutathione Peroxidase, ROS, GPX, Reactive Oxygen Species, p62, Ferroptosis
Related Pathways
Immunology/Inflammation, Oxidation-Reduction, Apoptosis, Metabolism, Autophagy, NF-κB
Purity
0.9996
Bioactivity
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM) . RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
Smiles
COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](N1C(=O)CCl)c1ccc(cc1)C(=O)OC
Molecular Formula
C23H21ClN2O5
Molecular Weight
440.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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