CAY10701
Product Specifications
CAS Number
1616967-52-2
Target
Microtubule Associated, Others
Related Pathways
Cytoskeletal Signaling, Others
Bioactivity
CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively) . It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body weight.
Smiles
C(=O)(C1=C(C2=C(N1)NC(CCCC#C)=NC2=O)C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C24H19N3O2
Molecular Weight
381.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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