(E) -Ajoene

(E) -Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 ?g/ml, respectively) and fungi (MICs = 15-50 ?g/ml) .1 (E) -Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 ?M, respectively) .2It also inhibits human glutathione reductase andT. cruzitrypanothione reductase when used at a concentration of 200 ?M.3 (E) -Ajoene (25 mg/kg) is neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region.4